Last year marked the 500th anniversary of the death of the greatest artist in history and it has been a year of celebration and recognition. The Italian genius, the ultimate Renaissance Man, was not only the greatest painter of all time, his interests include extraordinary inventions, drawing, sculpture, architecture, science, music, mathematics, engineering, literature, anatomy, geology, astronomy, botany, paleontology, and cartography. My lecture will focus on his paintings, using the great masterpiece, Mona Lisa, as the introduction to his work. Dr. Carol Damian is the former Professor of Art History in the School of Art and Art History and former Director and Chief Curator of the Patricia and Phillip Frost Art Museum at Florida International University.